Researchers were successful in developing a genetically modified (GM) rice that can reduce high blood pressure when consumed, without any side effects.
Scientists from the Chinese Academy of Sciences genetically modified a variety of rice by introducing a gene that consisted of nine angiotensin converting enzyme (ACE)-inhibitory peptides plus a blood-relaxing peptide linked together. ACE inhibitors are synthetically-produced drugs used to treat hypertension but are known to have a variety of side effects ranging from skin rashes to kidney impairment. However, the ACE inhibitory peptides introduced into the GM rice came from natural sources and are known to have fewer side effects. Some examples of food sources of natural ACE inhibitory peptides are milk, eggs, fish, meat and plants.
Once the researchers were able to confirm that high levels of peptides were present in the GM rice, they extracted the peptides from its seeds and intragastrically administered them into hypertensive rats. The rats were observed to have a significant decrease in their systolic blood pressure after only two hours. Moreover, it was also observed that the rats fed with GM rice flour for five weeks had consistent improvement and remained so a week after the treatment stopped. The researchers also noted that there were no effects on growth, development, or blood chemistry of the treated rats. They concluded that their work can be an alternative source of natural antihypertensive agents should the peptides have the same effect on humans.
Quian et al. (2020) Hypotensive Activity of Transgenic Rice Seed Accumulating Multiple Antihypertensive Peptides. Journal of Agriculture and Food Chemistry; https://doi.org/10.1021/acs.jafc.0c01958
Source: Crop Biotech Update